MOTS-C

MOTS-c is a mitochondrial-derived peptide studied for its role in metabolic regulation, cellular stress response, glucose handling, and energy homeostasis. Unlike many peptides encoded by nuclear DNA, MOTS-c is derived from mitochondrial DNA, making it especially interesting in aging and metabolism research. It has been investigated for its ability to influence AMPK signaling, skeletal muscle metabolism, insulin sensitivity, and adaptive responses to metabolic stress. Researchers value MOTS-c because it connects mitochondrial communication with whole-body energy regulation. It is frequently discussed in studies related to longevity, exercise biology, and age-associated metabolic decline.